The high-risk variant, ApoE4, triggers an inflammatory reaction that weakens the blood-brain barrier, a network of cells and other components that lines brain vessels, which would normally create a barrier to nutrients into the brain and keep harmful substances out, according to a study published May 16 in Nature. Researchers have found that in mice, having the most risky variant of ApoE damages the blood vessels that feed the brain.
Major advances have been made in the development of Alzheimer’s disease (AD) biomarkers in the last two decades, with models of the temporal evolution of AD biomarkers offering the possibility of staging the course of the disease. Despite the achievements in this field, a major unmet need is the standardization of quantitative metrics for AD imaging biomarkers, according to an article published in the May issue of Radiology.
The Alzheimer's Association has awarded its largest research grant—nearly $4.2 million over four years—to the Dominantly Inherited Alzheimer's Network-Therapeutic Trials Unit, based at Washington University School of Medicine in St. Louis, to enable the program to move forward with drug and biomarker trials in people with genetically based, young-onset Alzheimer's disease.
Revised criteria for the diagnosis of mild cognitive impairment (MCI) could compromise the diagnosis of Alzheimer disease (AD) dementia, according to an analysis published online Feb. 6 in Archives of Neurology.
The Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium has released biomarker data from studies intended to improve the ability to diagnose and measure the progression of Alzheimer’s disease.
This article discusses the recent updates in Alzheimer’s detection using amyloid PET radiotracer 18F-flutemetamol, proteins in the cerebrospinal fluid and blood.
18F-FDG PET may provide a quantitative measure to detect progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD), and could offer a mechanism to streamline clinical trials, according to a study published in this month's Journal of Nuclear Medicine.
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