After surviving childhood cancer, patients who experience a subsequent neoplasm face a large increase in the risk of developing additional neoplasms, with more than one-quarter developing third or subsequent tumors, and particularly high rates found among those treated for nonmelanoma skin cancers, according to the authors of a large study published June 27 in the Journal of Clinical Oncology.

Nordion has received FDA approval to conduct a phase III clinical trial for TheraSphere under an Investigational Device Exemption (IDE). The trial will examine the safety and effectiveness of TheraSphere when the treatment is added to standard kinase inhibitor therapy in patients with unresectable hepatocellular carcinoma.